Download Video: Manchester United vs Leicester City 2-1 – Highlights
Puel puts Maguire in the middle of the defence, although he has had little time to prepare after being given extended time away after the World Cup.
Vardy is left on the bench as Iheanacho leads the line, supported by new signings Maddison and Ricardo Pereira along with Gray.
Mourinho hands a Premier League debut to Fred in the middle of the park alongside Andreas Pereira and Pogba, who starts despite being just four weeks removed from the World Cup final and having had no time in pre-season on the field.
Rashford also starts to lead the line after playing deep into the competition with England. Lukaku starts on the bench with Fellaini and Young, completing the World Cup returnees.
Leicester City subs: Jonny Evans, Jamie Vardy, Marc Albrighton, Danny Ward, Vicente Iborra, Christian Fuchs, Rachid Ghezzal.
LEICESTER CITY (4-2-3-1): Kasper Schmeichel; Daniel Amartey, Wes Morgan, Harry Maguire, Ben Chilwell; Wilfried Ndidi, Adrien Silva; Ricardo Pereira, James Maddison, Demarai Gray; Kelechi Iheanacho.
Manchester United subs: Romelu Lukaku, Anthony Martial, Chris Smalling, Lee Grant, Ashley Young, Marouane Fellaini, Scott McTominay.
MANCHESTER UNITED (4-3-3): David de Gea; Matteo Darmian, Eric Bailly, Victor Lindelof, Luke Shaw; Fred, Andreas Pereira, Paul Pogba; Juan Mata, Marcus Rashford, Alexis Sanchez.
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